Mesothelioma Pages

September 2, 2010

National Mesothelioma Awareness Day for September, 2010

Filed under: Uncategorized — MesoPages @ 6:51 am

Representative Betty McCollum and Senator Patty Murray have introduced a motion to establish September 26th as “National Mesothelioma Awareness Day,” a day committed to rallying support for the disease’s victims.

Mesothelioma, a rare and aggressive cancer of the soft tissue which encases the body’s vital organs, claims some ninety to one-hundred thousand lives each year worldwide. The disease has been positively linked with exposure to asbestos, a substance used frequently as an insulator and sealant, and as an additive in many industrial compounds.

While knowledge of the adverse effects of asbestos was established in the early twentieth century, many governments have been slow to adopt laws that could curb exposure to the dangerous substance. Around fifty-two nations around the globe, including the vast majority of the European Union as well as Australia and New Zealand, have completely banned asbestos from the industrial market. America, Britain, Russia, China and Canada, however, have thus far failed to implement a total ban but instead have introduced strict regulations and restrictions.

In the United States, a total ban on asbestos was attempted in the late 1980′s. The law, proposed by the Environmental Protection Agency, was overturned just a few years later by asbestos industry corporations seeking to protect their profits.

The recognition of National Mesothelioma Awareness Day hasn’t been passed into law yet. The bill, also known as H. 771, is mired in the house’s Committee on Oversight and Government Reform, which is chaired by Representative Edolphus Towns.

The search for a mesothelioma cure, however, and the effort to increase the public’s awareness of the disease, are gaining more support today than any time in the past. Florida, for example, passed a bill last year instating the twenty-sixth of September as the state’s own Mesothelioma Awareness Day. It will be recognized for the first time this year.

The Mesothelioma Applied Research Foundation, commonly referred to as the Meso Foundation, is playing a huge role in championing the cause. The organization is ramping up its efforts year after year, hosting marathons, conferences and other events to raise money, increase popular support, and call the medical community as well as the government to action.

The Meso Foundation has high hopes for the coming year. With the possibility of a National Mesothelioma Awareness Day taking place for the first time in 2010, they’re hoping to coordinate their efforts to maximize their campaign’s efficacy. Representatives of the Meso Foundation will be in New York on September 26th for the taping of the Today Show, and they will be placing awareness ads in the high profile 10 Rockefeller display window during the week surrounding the 26th.

Meanwhile, asbestos exposure continues to affect hundreds of thousands of lives each year. With the possible recognition of an annual Mesothelioma Awareness day starting in 2010, however, the disease’s ugly history may be breaching the beginning of the end.

August 25, 2010

Mesothelioma patient demonstrates incredible recovery

Filed under: Treatment — MesoPages @ 4:34 pm

Karen Grant is astonishing doctors with her unprecedented continuing good health in the face of a mesothelioma diagnosis now five years old. The vast majority of mesothelioma victims live just six to eighteen months after being diagnosed, regardless of their treatment options, general condition, age, gender or other factors.

Mesothelioma is an aggressive and terminal cancer which attacks the mesothelium, a soft tissue lining which encases the body’s vital organs. While researchers are constantly looking for better ways to treat the disease, medical practices surrounding the deadly cancer haven’t actually changed much in the last several decades. Much like other cancers, conventional treatments include surgery, chemotherapy and radiotherapy. Unlike some cancers, however, mesothelioma often doesn’t respond to these treatments.

Grant, a Massachusetts woman, battled the disease with a high risk treatment regimen recommended by Dr. David Sugarbaker, a surgeon working in Brigham and Women’s Hospital in Boston. Dr. Sugarbaker recommended a radical, invasive treatment which entailed two separate tumor removal surgeries, a direct application of warmed chemotherapy, and follow-up treatment of traditional chemotherapy and rehabilitation.

“We offered her a very aggressive approach, to which a lot of patients could have said no, thank you. But not Karen,” said Dr. David Sugarbaker.

Grant was diagnosed with the disease at just twenty-nine years old, some twenty to thirty years earlier than most mesothelioma patients are diagnosed. While diagnosis with a cancer hitherto considered fatal at such a young age is certainly a tragedy, she may have her youth to thank for eligibility for such radical treatment.

“It’s just incredible,” said Grant, “I never thought I’d look this good and be living the life.”

Grant’s lung screenings have continued to show no signs of recurring tumors or cancer cells, a phenomena that’s far from the norm with the vast majority of mesothelioma patients. Her oncologists are amazed, but at this point are willing to hope for the best.

“Five years is a huge benchmark,” says a spokesperson for the Dana-Farber Cancer Institute, Dr. Pasi Janne, “if another occurrence is going to happen, it is going to be more common in the first couple of years.”

Grant hopes that her story will help other mesothelioma patients to remain positive about their condition and their future.

Mesothelioma will continue to hound thousands of Americans each year as long as asbestos regulations are either unenforced, or themselves insufficiently strict. Manufacturers and distributors of asbestos laden products are entirely responsible for mesothelioma in America, and the disease will continue to be a problem until asbestos is completely banned.

August 18, 2010

Discovery could improve mesothelioma diagnosis process

Filed under: Treatment — MesoPages @ 7:55 am

Researchers in Australia recently made a discovery which could improve early diagnosis rates for mesothelioma, a rare and aggressive form of cancer caused almost exclusively by asbestos exposure. The scientists discovered that a specific family of proteins, known as serum mesothelin, can be detected in some mesothelioma patients at much higher than normal levels. The discovery suggests a correlation between the cancer and the protein family, and could contribute to developing a more effective battery of diagnostic tests for the disease.

Mesothelioma is a terminal cancer that affects some 90,000 people worldwide every year. In the United States, at least 3,000 people die annually after suffering with the cancer for an average of six to eighteen months. Mesothelioma is caused almost exclusively by exposure to asbestos fibers.

Asbestos, a fibrous mineral historically used as an insulator, sealant, and fire retardant, breaks apart easily into microscopic, hair like fibers. These fibers often enter the body accidentally either through inhalation or ingestion, but due to their unique shape pass easily through many tissues such as the lung wall or intestines. The fibers eventually become entangled in a soft, sticky tissue known as the mesothelium, where they cause a scarring reaction that can develop into a malignant tumor given enough time. Mesothelioma often takes ten to fifty years to fully develop.

Most individuals who suffer with mesothelioma were at one time exposed to asbestos fibers consistently through their place of employment. While examining an individual’s work history is still a critical part of a mesothelioma diagnosis, new methods of determining risk factors for the disease such as evaluating the level of the protein family serum mesothelin could increase early diagnosis rates. At present, only a biopsy can definitively confirm mesothelioma.

The serum mesothelin research involved measuring the levels of the protein family in a variety of individuals who had been exposed to asbestos fibers. The serum mesothelin levels where measured progressively at similar intervals as time passed. Of the patients who ultimately developed mesothelioma, some fifteen percent demonstrated dramatically higher levels of mesothelin directly before a positive diagnosis. Nearly forty percent of the test group showed a similar rise in mesothelin levels at the same time, but did not ultimately develop the disease. The researchers are still interpreting the results.

The mesothelin serum research does not in itself represent a more effective mesothelioma screening test. In the future, however, research like this could contribute to the development of more accurate screening tests for mesothelioma.

August 11, 2010

Study shows radical surgery may improve mesothelioma survival

Filed under: Treatment — MesoPages @ 1:05 pm

The European Journal of Cardio-Thoracic Surgery has published a new results of a new clinical trial which aimed to better understand the efficacy of certain radical surgery procedures. The study compared the results of two different treatment methods for malignant mesothelioma: radical open-lung-sparing decortication and palliative surgery.

Mesothelioma is an aggressive and terminal cancer caused by exposure to asbestos fibers. The cancer can affect several areas of the body, but the most common tumor site is the pleural mesothelium, a soft, protective tissue which encases the lungs. Mesothelioma is incredibly resilient. Curative treatments, or treatments which aim to remove the tumor and destroy remaining cancer cells with chemotherapy and radiotherapy, are often ineffective. In most cases palliative surgery is performed instead, a form of surgery which aims to improve the patient’s comfort without removing the cancerous growth.

Radical open-lung-sparing decortication refers to a procedure in which the mesothelial lining and the cancerous tumor are removed completely from the lung. Chemotherapy and radiotherapy regimens follow to kill any cancer cells remaining on or around the surgery site. The surgery is invasive and recovery often proves difficult.

Palliative surgery, on the other hand, aims solely to reduce swelling and drain fluid buildup that results from the body’s reaction to the cancerous tumor. The surgery relieves pain associated with the disease but doesn’t slow the spread of the cancer which will eventually prove fatal.

The recent trial compared 13 patients who opted for radical decortication with 13 other patients, matched for similar ages, medical history, body mass index and disease progression, who opted for palliative treatment.

“Patients were matched for age, sex, histology, computed tomography (CT) stage, haematological indices, body mass index (BMI) and adjuvant chemotherapy. We compared perioperative and postoperative courses and long-term survival,” write the study’s authors.

Results demonstrated that all types of cells in the radical surgery group out-survived those in the palliative surgery group. While technically that means that the radical surgery group fared better, the study doesn’t account for the patient’s quality of life.

“Radical open-lung-sparing surgery may confer a survival advantage to patients with malignant mesothelioma who are fit to undergo radical decortication followed by chemotherapy and radiotherapy,” states the study, “trials of radical surgery versus no surgery should include lung-sparing operations.”

http://www.mesopages.com/mesothelioma/

August 4, 2010

Study shows asbestos contamination in Sierra Nevada Foothills

Filed under: Uncategorized — MesoPages @ 4:49 pm

The Sierra Fund (TSF) has released the surprising results of a new study called the The Gold Country Recreational Trails and Abandoned Mines Assessment, which indicates that several areas in the Sierra Nevada Foothills are still dangerously contaminated with mining related toxins. The study investigates the long term ramifications of the Gold Rush era, and has found that arsenic, lead and asbestos persist in dangerous levels in several areas frequented by outdoor enthusiasts.

Elizabeth Martin, the CEO of the Sierra Fund, says: “More than 100 years after the end of the Gold Rush era, the environmental, cultural and health impacts of that time have still not been assessed or addressed. Our study documents that these abandoned mines pose a toxic health threat on public lands that are widely used for recreational activities. The time has come for a serious assessment of abandoned mines, and the public needs to be informed about potential exposure to toxic heavy metals and asbestos in areas with abandoned mines.”

The study sites the analyses of soil samples taken from hiking trails and other public areas around abandoned mines, waste rock piles, and mine tailings in Downieville, Nevada City, and Foresthill. Almost half of the soil tested contained dangerous amounts of asbestos dust, and lead was often present at eighteen times the concentration considered safe by state and federal regulations.

The dangerous chemicals are relics from the mining methods employed during the gold mining craze of yesteryear, while the asbestos dust comes from serpentine – a rock that’s abundant throughout California – which has been crushed into powder during mining operations. Exposure to asbestos has been positively linked with the development of mesothelioma, an aggressive and terminal cancer. According to the United States Food and Drug Administration there is no safe level of exposure to asbestos.

A spokesman for the Central California division of the Bureau of Land Management says that decontaminating the area is virtually impossible because the pollutants are so abundant and so thoroughly blended with the surrounding terrain. The Sierra Fund is advocating the placement of warning signs in the area, and the restriction of public access to specifically dangerous areas.

July 29, 2010

Senator John Tester works to improve hospitals in Libby, Montana

Filed under: Uncategorized — MesoPages @ 6:04 am

Senator John Tester introduced a new measure this week that could introduce a more effective medical staff to Libby, Montana, where thousands may face complicated medical problems.

Libby was the home of one of the United State’s largest vermiculite mines for nearly one hundred years. Vermiculite, a natural mineral that’s useful for a variety of purposes, contains substantial amounts of deadly asbestos fibers. W.R. Grace and Co., the company that owned the mine since its opening in 1919, was indicted in 2005 for knowingly endangering the residents of Libby. The Environmental Protection Agency (EPA) claimed that W.R. Grace and Co. had been intentionally suppressing findings about the ill effects of asbestos containing vermiculite since the 1970′s.

Today, some 1,200 Libby residents have suffered from asbestos related illnesses, including the aggressive and terminal cancer mesothelioma. Libby hospitals are having a difficult time dealing with additional stress on their medical systems, and some fear that their lack of specialists could pose a potential threat to those affected by asbestos exposure.

Tester’s proposal could change all that.

The National Health Service Corps, a federal program that’s been in place since the 1970′s, was put into place to recruit doctors to under served, rural markets. The program offers benefits such as medical school scholarships and loan repayment for general practitioners who are willing to re-locate.

Tester’s plan is to amend the program to allow specialists to participate as well as general practitioners, granted they’re willing to work in an area designated as a “public health emergency.” Just last year on June 17, after evaluating the results of various asbestos contamination tests in the area, the EPA declared Libby, Montana as the very first public health emergency.

“This is going to really open some doors,” said the Senator Monday, while he was describing his plan.

Tester believes that obtaining proper health care in an area like Libby is very difficult without special provisions. In addition to being in a rural, far from densely populated area, Libby’s asbestos contamination itself constitutes a deterrent to many doctors and specialists.

“It is increasingly difficult,” reads Tester’s bill, “for the health care facilities in [areas like Libby] to recruit the specialists necessary.”

If passed, the bill could help to create incentives for specialized practice in Libby, Montana, and alleviate the pressure on an over-strained medical staff.

July 22, 2010

Trial studies new mesothelioma treatment method

Filed under: Treatment — MesoPages @ 5:45 am

Interactive Cardiovascular and Thoracic Surgery, an online journal, recently published a study entitled Cold-Plasma Coagulation in the Treatment of Malignant Pleural Mesothelioma. The study discusses research which introduced a new component of multi-modal surgery, cold-plasma coagulation, in an attempt to improve survival rates in mesothelioma patients.

Mesothelioma, an aggressive and terminal cancer caused almost exclusively by asbestos fibers, claims nearly one hundred thousand lives every year. The disease takes several years or even decades to develop in those who have been exposed to asbestos fibers, which has created a large lapse in the correlation between the prevalence of asbestos and new diagnoses of the disease.

The disease results from a peculiar scarring that asbestos causes on a specialized tissue known as the mesothelium. When asbestos fibers are inhaled or ingested, they easily pass through many of the body’s tissues due to their microscopic size and strange, needle-like shape. Unfortunately, they easily become entangled in the mesothelium, a sticky tissue which helps to lubricate the body’s vital organs. The sharp asbestos fibers cause damage to the mesothelium, and the scarring which results can eventually develop into malignant tumors.

Mesothelioma treatment is palliative, meaning that it aims to increase the patient’s comfort rather than cure the disease. Generally consisting of a combination of surgery, chemotherapy, and radiotherapy, treatments work to remove tumors, alleviate pressure caused by swelling and fluid build-up, and slow the spread of malignant cells.

In recent years, a method known as heated chemotherapy has joined the ranks of well known mesothelioma treatments. Heated chemotherapy consists of administering a heated chemotherapy solution directly to affected tissues during and after surgical procedures. While the heated chemotherapy has been shown to absorb more effectively into the affected tissues, it has also been known to cause mild damage to the diaphragm and pericardium – the tissue protecting the heart.

Cold-plasma coagulation, or CPC, was introduced by a German research team as an additional element of multi-modal therapy. Administering CPC before heated chemotherapy has shown promise in more thoroughly eliminating malignant cells in the diaphragm, pleura, and pericardium and limiting the damage which the heated chemotherapy can potentially cause.

The study’s authors were careful to limit the implications of their research, saying: “We consider our trial as a pilot study. To evaluate potential survival benefits using this [Cold Plasma] technique, larger trials are mandatory.”

July 14, 2010

Global Outrage Caused by the Expansion of Canadian Asbestos Mine

Filed under: Uncategorized — MesoPages @ 10:36 am

This year the provincial government of Quebec plans to finance the expansion of the Jeffrey Mine located in the small northern town of Asbestos, named after its most valuable and abundant resource. This decision has incited an aggravated global awareness which has protesters all over the world voicing their concerns about investment into the asbestos industry. Prolonged asbestos exposure can cause extreme health problems including mesothelioma, a form of lung cancer which is almost always fatal.

With the provincial government’s funding approval, the new mining operation would generate close to 200,000 tons of asbestos each year. The majority of this asbestos would then be shipped to developing countries all over the world which often lack the safe handling laws that protect workers from asbestos related illnesses. South Korea, Belgium, Hong Kong and an assortment of North American cities have organized peaceful protests in an attempt to stress the severity of asbestos related diseases.

In Hong Kong, protesters gathered outside the Canadian consulate, calling for a ban on asbestos exports between the two countries. According to the Asia Monitor Resource Center, Hong Kong is in the midst of an asbestos disease epidemic, with more and more workers dying each year on account of lung cancer and mesothelioma. Even if asbestos exports cease immediately, mesothelioma’s tendency to lie dormant means citizens could potentially experience symptoms for another 30 years.

Since the beginning of the 19th century, medical records have shown how potentially dangerous asbestos can be. Mesothelioma, scarring of the lung tissue, and asbestos warts caused by sharp fibers being lodged in the skin can all be triggered from asbestos contamination. While employers, manufacturers and property owners have been aware of these problems for several years, many have failed to take the actions necessary to safeguard their employees and consumers. These types of behavior have resulted in unnecessary deaths as well as thousands of asbestos lawsuits.

In past years, lawyers have had great success in mesothelioma cases, often ending in multi-million dollar settlements. However, the medical advances concerning asbestos diseases are not so encouraging, with nearly 3,000 Americans being diagnosed each year with the potentially fatal disease.

Despite global disapproval many Canadians see things differently. Many locals are excited for the mine’s expansion, hoping that it will alleviate suffering in the local economy. Some local companies have even banned together to raise an additional two million dollars to help fund the massive project.

Protesters all over the world disagree, stating that the mine’s expansion will increase needless asbestos contamination and lead to further disease.

July 7, 2010

Researchers uncover new mesothelioma secrets

Filed under: Uncategorized — MesoPages @ 9:08 am

According to research recently published in the Proceedings of the National Academy of Sciences, new steps are being taken toward a more complete understanding of mesothelioma.

One of the more confusing aspects of the disease lies in the fact that asbestos exposure seems to both kill cells and cause the growth of malignant tumors – reactions that appear mutually exclusive seeing as dead cells can’t multiply. A group of scientists and researchers at the University of Hawaii believe they’ve uncovered some important details about this phenomena, details that could lead to new treatments with more research and development.

Mesothelioma is an aggressive cancer caused almost exclusively by exposure to asbestos fibers. One of the curiosities of the disease is what’s referred to as its “latency period”, that is, the long amount of time that passes between exposure to asbestos fibers and the development of malignant tumors. In many cases this latency period can be as long as thirty to even fifty years.

Mesothelioma’s latency period has been a source of particular frustration and difficulty for a variety of reasons. In addition to obscuring the connection between the mineral and the disease, a phenomena which allowed asbestos companies to contaminate workplaces unchecked for decades, the latency period also complicates diagnosis. Many patients don’t associate mesothelioma’s general ailment, flu like symptoms with workplace asbestos exposure which took place decades in their past.

The research team in Hawaii has uncovered a connection between two of mesothelioma’s odd traits: the fact that it somehow kills cells and encourages tumor growth simultaneously, and the fact that it takes decades to present malignant growths.

Their research has shown that asbestos kills cells through a process known as programmed cell necrosis, a process which leads to the release of a particular protein called HMGB1. The released HMGB1 protein causes an inflammatory reaction in surrounding tissues, which in turn releases mutagens that eventually leads to tumor growth. The researchers believe that if the release of HMGB1 and the resulting tissue inflammation could be controlled or prevented, the release of mutagens would not be triggered and malignant tumors may never develop.

A clinical trial will be conducted in Cappadocia, Turkey, an area highly affected by asbestos exposure, to gain more insight on their findings and further develop their approach. If the results of the trial are encouraging, further tests and additional time could lead to the development of new treatment methods for mesothelioma.

June 29, 2010

EPA and Marco Island, FL reach agreement over asbestos incident

Filed under: Uncategorized — MesoPages @ 4:21 am

Marco Island, Florida has reached an agreement with the Environmental Protection Agency after a four year ordeal that unfolded after an infrastructure re-engineering project was conducted improperly by one of the city’s contractors. Quality Enterprises, the contractor chosen to widen sewer lines and improve a highway several years ago, came under investigation after an anonymous tip accused them of incorrectly handling asbestos waste. The allegations claimed that asbestos laden pipes were broken up and disposed without the special regard required for such materials by state and federal regulations.

All in all, six violations of the Clean Air Act were reported. The accusations included: the improper inspection of an area containing asbestos, failure to have an asbestos hazard trained staff member on site, failure to remove asbestos before aggravating the material, and failure to dispose of asbestos as soon as practically possible. Quality Enterprises was also accused of not handling the materials properly even though they were aware that it was a dangerous health hazard.

Regulations and restrictions surrounding asbestos materials were put in place to protect the health of both construction and demolition workers as well as the general public. While asbestos has been used in a variety of different ways in the construction and engineering industries for more than a century, its toxicity has moved closer and closer to center stage over the past twenty-five years.

Asbestos causes several serious and fatal diseases such as asbestosis, lung cancer, mesothelioma and various respiratory ailments. The EPA attempted to ban the material from use in the 1980′s, but was overpowered by a powerful, threatened asbestos industry fueled by both heavy industry and national defense contracts. Nowadays, the material is legal throughout the United States but its use is heavily restricted. Special licenses and careful procedures are required when handling asbestos containing construction materials.

The settlement reached between Marco Island, Quality Enterprises and the EPA will hold Quality Enterprises financially responsible for the asbestos hazard without requiring either party to admit guilt to the Clean Air Act infractions. The penalties for the six infractions are just $82,772, a fairly small price to pay after four years of deliberation.

Frank Recker, the chairman of the Marco Island City Council, felt that holding the contractors technically responsible instead of the city that agreed to hire them was an important victory for Marco Island.

“It was Dr. [interim City Manager Jim] Riviere’s and my mission,” said Recker, “to get the world to understand we didn’t think the city was financially responsible for anything.”

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