Mesothelioma Pages

January 26, 2011

Asbestos awareness follows growing exposure risks

Filed under: Uncategorized — MesoPages @ 10:46 am

The Asbestos Disease Awareness Organization (ADOA) will host a conference in Atlanta, Georgia to inform and educate the public on the growing threats of asbestos exposure. The ADOA and groups like it are closely following the recent asbestos exposure crisis in Las Vegas, Nevada, at the Flamingo Hotel.

During renovations at Flamingo Hotel asbestos was allegedly exposed in large amounts and was referred to as a threat to public health. With an abundance of national regulations covering the use and abatement of asbestos the federal government became involved to investigate the happenings at the Flamingo. The renovations were being done to keep the property up to US Occupational Safety and Health Administration (OSHA) codes.

This would not be the first time repairs attempting to keep facilities on par with national health standards have been the cause of violations against those very regulations. Particularly difficult are the cases of asbestos abatement; tampering and removing damaged or worn materials can potentially cause greater exposure risks than leaving the containing materials untouched.

Asbestos was used heavily in the US before the 1980s. Now, as materials used in original construction are wearing out, asbestos, which was once safely contained in building components, is becoming free and airborne.  This is a greater problem in schools and municipal buildings with longer times of use and higher traffic patterns within the same structure.

Airborne asbestos fibers can cause fatal respiratory conditions. Mesothelioma is a rare cancer of the mesothelium, lung lining, which is caused almost solely be asbestos fibers. If inhaled, asbestos fibers can begin a mutation process in the mesothelium and lining of other abdominal cavities, which grows into irregularly patterned tumors.

Mesothelioma claims about three thousand American lives annually. It takes decades to develop making it extremely difficult to diagnose. Patients who do not know they were exposed to asbestos may have mesothelioma for much of their lives with no idea they are ill at all. Symptoms begin to show twenty to fifty years after development begins. They include wheezing and coughing which further postpones proper diagnoses being taken for pneumonia or other respiratory illnesses. Although mesothelioma treatments exist, there is no known cure.

Although the Environmental Protection Agency (EPA) describes asbestos regulations in their Clean Air Act, many individuals and companies choose to violate these laws rather than follow them. Public health and safety is put at risk when illegal, profit-saving methods are used to cut corners in proper removal, disposal and clean up of asbestos.

January 19, 2011

Studies show pemetrexed-based drugs may be a good second-line defense for mesothelioma patients

Filed under: Treatment — MesoPages @ 9:03 am

New studies are showing pemetrexed-based chemotherapy drugs may be a good second-line treatment option for mesothelioma patients who used the same drug type as a first defense.

Pemetrexed fights cancer by inhibiting the formation of DNA and RNA in targeted cells. Without DNA and RNA both cancer and regular cells are unable to survive or grow. Although pemetrexed drugs are currently used as a first line of defense against mesothelioma, no relapse treatment has been approved for use.

A study done by Italian researchers published in medical journal Lung Cancer, reported findings on pemetrexed-based chemotherapies to be beneficial in certain instances as a mesothelioma relapse treatment.

In the study discussed, 31 mesothelioma patients who used pemetrexed-based chemotherapy in at least one prior treatment regime were administered the same pemetrexed-type drugs for relapse between 2004 and 2009. All patients were given second-line, same-type treatments at least 3 months after the last dose of prior treatments. Fifteen patients received pemetrexed chemotherapies while 16 received a combination of pemetrexed/platinum treatments.

Forty-eight percent of patients in the study responded well, with shrinking tumors or tumors that stopped growing. A key in the second-line use of pemetrexed-based drugs seemed to be in patient response to first-defense treatment using the same drug type. Patients who responded to the first pemetrexed-based treatments with at least a 12 month progression-free period responded to same-type second-line treatments with another 5.5 months progression-free period, on average. Patients not gaining as much as 12 months progression-free from the first pemetrexed-based treatments, averaged only 2.5 months progression free following same-type second treatments.

Mesothelioma patients average an eighteen-month life expectancy following diagnosis, although survival rates range from six months to five years. A rare cancer, mesothelioma affects about 3000 families in America each year. Mesothelioma is caused almost solely by exposure to the toxic chemical asbestos. If inhaled, asbestos fibers can begin a damaging process in lining of abdominal cavities, which grows into irregularly patterned malignant mesothelioma over several decades.

Mesothelioma treatments include any combination of surgery, chemotherapy and radiation therapy. Non-cancer direct treatment is available for patients wishing to focus on pain management and quality of life. There is no known cure for mesothelioma.

Another study, by Japanese researchers, with similar results was published in the International Journal of Clinical Oncology. Researchers stated that mesothelioma patients who showed good responses to first-time pemetrexid-based drug treatment were more likely to benefit from same-type second-line treatment. Study authors suggested additional research to decide how to best manage mesothelioma relapse cases.

January 12, 2011

Japanese researchers test potential mesothelioma drug

Filed under: Treatment — MesoPages @ 10:25 am

Cancer, chemotherapy and Pharmacology, a medical journal, recently published an article pertaining to a new drug developed in Japan. Japanese researchers are testing S-1 for its potential as a pleural mesothelioma treatment.

S-1 was designed to reduce tumor growth while supporting another anti-cancer drug, 5-FU. Used in Japan, Korea, China and other Asian countries in the fight against gastric cancer, S-1 has been recommended for approval to be used to treat the same in Europe. It is currently not available in the US.

Developed by Taiho Pharmaceutical Company, S-1 goes by its brand name Teysuno.

Studies were done at the University of Tokushima using lab mice. Malignant mesothelioma cells were administered into the chest cavities of the mice and allowed to grow for quite some time. This development time was used to simulate the late stages of mesothelioma that are typically diagnosed in humans—well after original development begins. When given S-1 the mice responded with reduced tumor size and longer survival times.

Mesothelioma is caused almost exclusively by asbestos fibers. Asbestos has been used heavily in the past hundred years around the world and continues to be used in developing countries. Until worldwide asbestos use is stopped completely, mesothelioma case numbers are expected to rise.

If inhaled, asbestos fibers begin the growth of mesothelioma by mutating the cells of lung lining or lining of other abdominal cavities. Tumor systems affecting lung lining are called pleural mesothelioma, while the less common peritoneal mesothelioma affects lining of other abdominal cavities. Patients often have no idea they were exposed to asbestos and never see a specialist until twenty to fifty years later when symptoms start to show. Even then, diagnosis is difficult as signs mirror those of pneumonia and other respiratory conditions.

Mesothelioma treatments include chemotherapy, surgery and radiation therapy when the patient chooses a cancer-direct approach. However, as there is no known cure for mesothelioma, many patients are undergoing palliative care to manage pain and raise quality of life. Life expectancy following diagnosis of mesothelioma averages eighteen months.

Japanese researchers working on the S-1 studies are encouraged by its outcomes so far. They are calling S-1 a possible good drug to control pleural mesothelioma.

January 5, 2011

Marriage and community stays together through mesothelioma

Filed under: Uncategorized — MesoPages @ 10:27 am

For one couple in Platteville, Wisconsin, “through sickness and health” is ringing true. After 41 years of marriage Ralph and Kathy Bjork are being tested by their wedding vows taken so long ago.

Following a diagnosis of multiple sclerosis Ralph lost all physical ability other than slight head movement. Through his worsening condition, his bride Kathy has stayed by his side and cared for his needs.

Recently, Kathy was diagnosed with rare cancer mesothelioma. Struggling with symptoms for a while, the diagnosis was a grim surprise. Quickly losing her own strength, Kathy and Ralph now both rely on others for their care.

Mesothelioma affects about three thousand Americans each year. Characterized by a long latency period, many mesothelioma patients have no idea they have been struggling with cancer until decades after development started. Although there are many mesothelioma treatments available, there is no known cure.

Mesothelioma is almost solely caused by toxic chemical asbestos. Asbestos is present in countless building materials and is perhaps most commonly associated with floor and ceiling tiles in homes and offices. Although non-threatening when contained inside these materials, asbestos dust can cause severe health problems. Once asbestos fibers become airborne, the risk is high. If inhaled, asbestos fibers can begin a mutation in lung lining and lining of other abdominal cavities, which grows into mesothelioma. Asbestosis and lung cancer can also be caused by asbestos fibers.

Construction, remodeling and wear and tear are some reasons behind airborne asbestos fibers. When asbestos containing materials such as floor and ceiling tiles are worn down or broken down for removal, asbestos dust is released. Kathy Bjork suspects asbestos removal, which took place in her office some 25 years ago, to be the catalyst for her disease. A common problem in older homes and buildings, asbestos exposure has become a leading issue in the American environmental arena.

As health risks related to asbestos began to be proven, use of the material died down. In the 1980s the US took a hard line on asbestos and began strictly regulated its use. The Environmental Protection Agency’s Clean Air Act describes Americans’ responsibilities to maintain and protect the quality of American air. However, safe and approved removal of asbestos is a costly business, and corners are often cut leaving workers and the public at risk of exposure.

Kathy Bjork has joined an experimental mesothelioma program at University of Chicago Medical Center. The Bjork’s sons, as well as medical professionals, have taken over Ralph’s care at this time. In light of the growing medical bills, the Bjorks are receiving great support from the community. Lutheran Church of Peace is organizing a benefit to help them offset medical expenses not covered by insurance.

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